Approaches
Lab Techniques
RODENT WORK

Two-photon imaging in navigating mice
We use in vivo two-photon imaging of multiple neurons and astrocytes over long periods of time in mice navigating in virtual reality environments.
Neuropixels recordings in navigating mice
We use in vivo Neuropixels recordings in mice navigating in virtual reality and real environments, including long-term recordings in smart-Kages.


Fully automated phenotyping of spatial and object memory and other behaviours in smart-Kages
We use our recently developed home cage systems (smart-Kages) to perform fully automated long-term phenotyping of complex behaviours including spatial working memory, object and object-location memory and multiple locomotion activities. We combine behavioural phenotyping with neural recordings to investigate neural circuits underlying these complex behaviours.
Virtual Reality
We use virtual reality to probe navigational abilities and memory performance in mice.


Hippocampal-based brain-machine-interface (BMI)
We develop and use hippocampal/entorhinal-based brain machine interface to control navigation directly from hippocampal/entorhinal neural activity patterns.
HUMAN WORK
Human Work
We develop and use mobile App based systems for long-term unsupervised cognitive and behavioural phenotyping in humans to facilitate early detection and monitoring of entorhinal-hippocampal related cognitive impairments, including Alzheimer’s disease.
