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Approaches

Lab Techniques

RODENT WORK

Two-photon imaging in navigating mice

We use in vivo two-photon imaging of multiple neurons and astrocytes over long periods of time in mice navigating in virtual reality environments.

Neuropixels recordings in navigating mice

We use in vivo Neuropixels recordings in mice navigating in virtual reality and real environments, including long-term recordings in smart-Kages.

Fully automated phenotyping of spatial and object memory and other behaviours in smart-Kages

We use our recently developed home cage systems (smart-Kages) to perform fully automated long-term phenotyping of complex behaviours including spatial working memory, object and object-location memory and multiple locomotion activities. We combine behavioural phenotyping with neural recordings to investigate neural circuits underlying these complex behaviours.

Virtual Reality

We use virtual reality to probe navigational abilities and memory performance in mice.

Hippocampal-based brain-machine-interface (BMI)

We develop and use hippocampal/entorhinal-based brain machine interface to control navigation directly from hippocampal/entorhinal neural activity patterns.

HUMAN WORK

Human Work

We develop and use mobile App based systems for long-term unsupervised cognitive and behavioural phenotyping in humans to facilitate early detection and monitoring of entorhinal-hippocampal related cognitive impairments, including Alzheimer’s disease.

Get in touch

Dementia Research Institute, University College London,

Cruciform Building, Gower St, London WC1E 6BT, UK

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